Endocrine Abstracts

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

Background: Cushing’s syndrome (CS) and hypertension (HT) are associated with alterations of coagulation. This is the first study that compares parameters of fibrin clot and fibrinolysis in CS with patients with essential hypertension (EHT) and healthy normotensive controls (HC).Methods: The patients were recruited at the university hospital of Ludwig-Maximilians-Universität München (Germany) and the Department of Hypertension, Institute o...

The ability of thyroid hormones to regulate body temperature is well established. While the active hormone T3 can act peripherally to induce thermogenesis in fat and muscle, it also acts centrally in the brain to increase body temperature through the sympathetic nervous system. Most remarkably, recent studies show that T3 treatment in mice causes an elevated body temperature even at 10°C, far below thermoneutrality, suggesting that the T3 effect constitutes pyrexia rather...

Background and Aim: Type 2 diabetes mellitus (T2DM) disparately affects ethnic groups. Prevalence is higher in Asian and Black ethnicities, and these patients suffer increased rates of some diabetes-related complications. Bariatric surgery is an effective treatment for T2DM and can lead to complete diabetes remission. The aim of this study was to assess if T2DM remission rates at 1-year following bariatric surgery vary between different ethnicities.Metho...

Dopamine agonists can falsely elevate plasma and urinary metanephrines, thus making the diagnosis of pheochromocytomas in patients taking these medications challenging. We present the case of an 80-year-old female care home resident with a background of hypertension, Parkinson’s disease (PD), dementia and pernicious anaemia. She presented with weight loss, unilateral leg swelling and abdominal distension. A computed tomography (CT) showed a 5.6 cm heterogeneously enhancin...

Background: Proton beam therapy (PBT) compared to photon-based radiotherapy (XRT) offers the benefit to administer lower radiation doses to critical organs thereby possibly minimizing the risk of sequelae in patients with residual craniopharyngiomas (CP) after hypothalamus-sparing surgery. The validation in large CP patient cohorts is still pending. Methods: Of 290 childhood-onset CP patients included 2007-2019 in the prospective multicenter trial Kranio...

Objective: Hypothalamic syndrome (HS) in childhood is a rare condition. Its epidemiology is not well known because incidence and prevalence are related to very rare underlying diseases. In addition, different criteria for the syndrome are used across studies. Recognizing HS may be difficult, due to its rareness and variety of symptoms. Having diagnostic criteria for signs and symptoms of hypothalamic dysfunction may aid in early recognition and diagnosis, in the reporting and ...

Polycystic Ovary Syndrome (PCOS) is the most common endocrinological dysfunction among women of reproductive age, often featuring hyperandrogenemia and anovulation. Reciprocal effects exist between elevated LH, androgens, anovulation and other features, increasing the hormonal disbalance, while the origins of PCOS are still not fully clear. The neuropeptides Phoenixin-20 (PNX20) and Nesfatin1 (NES1) are being co-expressed and thought to play opposing roles in the hypothalamic&...

Backgrounds: Preoperative diagnosis of parathyroid carcinoma (PC) is critical for the determination of the scope of surgical intervention. Nowadays, specific diagnostic markers for differentiation of PC and benign tumors are unknown, and less than half of patients with PC undergo necessary en bloc surgery.Aims: To develop the instrument for preoperative diagnosis of PC.Materials and methods: A multi-center retrospective study inclu...

Background: MEN1-related primary hyperparathyroidism (PHPT) characterised by benign course, whereas malignant transformation is extremely rare. The diagnosis of parathyroid carcinoma (PC) within the MEN-1 syndrome is a challenge for a range of specialists.Clinical case: A 47-year Eastern European female. PHPT had been revealed during examination for multinodular goitre: PTH 614 nmol\l, calcium 3.06 mmol\l. Results of imaging methods were controversial (m...